Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

Investor logo

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

BIENERTOVÁ VAŠKŮ Julie ZLÁMAL Filip POHOŘALÁ Aneta MIKEŠ Ondřej PÁVKOVÁ GOLDBERGOVÁ Monika NOVÁK Jan ŠPLÍCHAL Zbyněk PIKHART Hynek

Year of publication 2017
Type Article in Periodical
Magazine / Source BMC Medical Genetics
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1186/s12881-017-0454-z
Field Genetics and molecular biology
Keywords VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure
Description Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info