Unexpected therapeutic effects of cisplatin

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Authors

RAUDENSKÁ Martina BALVAN Jan FOJTŮ Michaela GUMULEC Jaromír MASAŘÍK Michal

Year of publication 2019
Type Article in Periodical
Magazine / Source Metallomics
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1039/c9mt00049f
Doi http://dx.doi.org/10.1039/c9mt00049f
Keywords VALOSIN-CONTAINING PROTEIN; SENSITIVE CHLORIDE CHANNELS; ENDOPLASMIC-RETICULUM STRESS; ANTICANCER DRUG CISPLATIN; COPPER TRANSPORTER CTR1; TUMOR-NECROSIS-FACTOR; NONMUSCLE MYOSIN IIA; BREAST-CANCER CELLS; MHC CLASS-I; INTRACELLULAR PH
Description Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.
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