Generic acquisition protocol for quantitative MRI of the spinal cord

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Authors

COHEN-ADAD Julien ALONSO-ORTIZ Eva ABRAMOVIC Mihael ARNEITZ Carina ATCHESON Nicole BARLOW Laura BARRY Robert L BARTH Markus BATTISTON Marco BÜCHEL Christian BUDDE Matthew CALLOT Virginie COMBES Anna J E LEENER Benjamin De DESCOTEAUX Maxime SOUSA Paulo Loureiro de DOSTÁL Marek DOYON Julien DVORAK Adam EIPPERT Falk EPPERSON Karla R EPPERSON Kevin S FREUND Patrick FINSTERBUSCH Jürgen FOIAS Alexandru FRATINI Michela FUKUNAGA Issei WHEELER-KINGSHOTT Claudia A M Gandini GERMANI Giancarlo GILBERT Guillaume GIOVE Federico GROS Charley GRUSSU Francesco HAGIWARA Akifumi HENRY Pierre-Gilles HORÁK Tomáš HORI Masaaki JOERS James KAMIYA Kouhei KARBASFOROUSHAN Haleh KEŘKOVSKÝ Miloš KHATIBI Ali KIM Joo-Won KINANY Nawal KITZLER Hagen KOLIND Shannon KONG Yazhuo KUDLIČKA Petr KUNTKE Paul KURNIAWAN Nyoman D KUSMIA Slawomir LABOUNEK René LAGANA Maria Marcella LAULE Cornelia LAW Christine S LENGLET Christophe LEUTRITZ Tobias LIU Yaou LLUFRIU Sara MACKEY Sean MARTINEZ-HERAS Eloy MATTERA Loan NESTRASIL Igor GRADY Kristin P O PAPINUTTO Nico PAPP Daniel PARETO Deborah PARRISH Todd B PICHIECCHIO Anna PRADOS Ferran ROVIRA Alex RUITENBERG Marc J SAMSON Rebecca S SAVINI Giovanni SEIF Maryam SEIFERT Alan C SMITH Alex K SMITH Seth A SMITH Zachary A SOLANA Elisabeth SUZUKI Yuichi TACKLEY George TINNERMANN Alexandra VALOŠEK Jan VILLE Dimitri Van De YIANNAKAS Marios C II Kenneth A Weber WEISKOPF Nikolaus WISE Richard G WYSS Patrik O XU Junqian

Year of publication 2021
Type Article in Periodical
Magazine / Source Nature Protocols
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41596-021-00588-0
Doi http://dx.doi.org/10.1038/s41596-021-00588-0
Keywords quantitative MRI; spinal cord
Description Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/ protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.
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