Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression

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Authors	PAVLOVA Iveta RUDÁ Jana
Year of publication	2023
Type	Article in Periodical
Magazine / Source	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.sciencedirect.com/science/article/pii/S0278584623000945?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.pnpbp.2023.110808
Keywords	Animal models Depression Proton magnetic resonance spectroscopy Metabolites
Attached files	Pavlova_Ruda_2023_PNBP.pdf
Description	This review summarises the current knowledge of 1H MRS findings from rodent models of MDD, assesses the results from both a biological and a technical perspective, and identifies the main sources of bias. From a technical point of view, bias-introducing factors are the diversity of the measured volumes and their positioning in the brain, the data processing, and the metabolite concentration expression.
Related projects:	National research infrastructure for biological and medical imaging Preclinical and clinical research in pharmacokinetics, neuropsychopharmacology and personalized pharmacotherapy in oncology Czech BioImaging: National research infrastructure for biological and medical imaging