Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

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Authors

RAUDENSKÁ Martina BALVAN Jan HÁNĚLOVÁ Klára BUGAJOVÁ Mária MASAŘÍK Michal

Year of publication 2023
Type Article in Periodical
Magazine / Source Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub
Doi http://dx.doi.org/10.1016/j.bbcan.2023.188940
Keywords Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy
Description Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
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