T1 mapping of myocardium in rats using self-gated golden-angle acquisition

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Authors

VITOUŠ Jiří JIŘÍK Radovan STRAČINA Tibor HENDRYCH Michal NÁDENÍČEK Jaroslav MACÍČEK Ondřej YE Tian KRÁTKÁ Lucie DRAŽANOVÁ Eva NOVÁKOVÁ Marie BABULA Petr PANOVSKÝ Roman DIBELLA Edward STARČUK Zenon

Year of publication 2024
Type Article in Periodical
Magazine / Source Magnetic Resonance in Medicine
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.29846?fbclid=IwAR1CLf31IELGKAL_vlDN3CVTIz7eLpGNhKlllj2n5hFk98Atx-W2j9mSW1E
Doi http://dx.doi.org/10.1002/mrm.29846
Keywords myocardium; T1 mapping
Description Purpose The aim of this study is to design a method of myocardial T1 quantification in small laboratory animals and to investigate the effects of spatiotemporal regularization and the needed acquisition duration. Methods We propose a compressed-sensing approach to T1 quantification based on self-gated inversion-recovery radial two/three-dimensional (2D/3D) golden-angle stack-of-stars acquisition with image reconstruction performed using total-variation spatiotemporal regularization. The method was tested on a phantom and on a healthy rat, as well as on rats in a small myocardium-remodeling study. Results The results showed a good match of the T1 estimates with the results obtained using the ground-truth method on a phantom and with the literature values for rats myocardium. The proposed 2D and 3D methods showed significant differences between normal and remodeling myocardium groups for acquisition lengths down to approximately 5 and 15 min, respectively. Conclusions A new 2D and 3D method for quantification of myocardial T1 in rats was proposed. We have shown the capability of both techniques to distinguish between normal and remodeling myocardial tissue. We have shown the effects of image-reconstruction regularization weights and acquisition length on the T1 estimates.
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