Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology-based treatment

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Authors

KRIŽANOVÁ Oľga PENESOVA Adela HOKYNKOVÁ Alica POKORNÁ Andrea SAMADIAN Amir BABULA Petr

Year of publication 2024
Type Article in Periodical
Magazine / Source International Wound Journal
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.14405
Doi http://dx.doi.org/10.1111/iwj.14405
Keywords chronic venous insufficiency; compression therapy; therapy; venous leg ulcers; wound coverage
Description The chronic venous disease covers a wide spectrum of venous disorders that are characterized by severely impaired blood return that primarily affects veins in the lower extremities. Morphological and functional abnormalities of the venous system led to chronic venous insufficiency (CVI), and present as leg heaviness/achiness, edema, telangiectasia, and varices. The term 'chronic venous insufficiency' (CVI) refers to a disease of greater severity. Venous dysfunction is associated with venous hypertension and is associated with venous reflux due to poorly functioning or incompetent venous valves, which ultimately reduces venous return, leading to a cascade of morphological, physiological, and histologic abnormalities such as blood pooling, hypoxia, inflammation, swelling, skin changes (lipodermatosclerosis), and in severe cases, venous leg ulcers (VLU). This review summarizes recent knowledge about the aetiology, risk factors, and pathophysiology of VLU and compared the possibilities of their treatment.
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