Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells

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Authors

LISKOVA Veronika CHOVANCOVA Barbora BABULA Petr REZUCHOVA Ingeborg PAVLOV Kristina Ploth MATUSKOVA Miroslava KRIŽANOVÁ Oľga

Year of publication 2023
Type Article in Periodical
Magazine / Source Frontiers in Oncology
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1178021/full
Doi http://dx.doi.org/10.3389/fonc.2023.1178021
Keywords cystathionine beta-synthase; cytoskeleton; beta-tubulin; colorectal carcinoma cells; xenografts
Description Background: Cystathionine beta-synthase (CBS), one of three enzymes that endogenously produce hydrogen sulfide, is extensively studied for its relevance in the cells of various tumors. In our previous work, we observed that the immunofluorescence pattern of CBS is very similar to that of tubulin and actin. Therefore, we focused on the potential interaction of CBS with cytoskeletal proteins beta-actin and beta-tubulin and the functional relevance of the potential interaction of these proteins in colorectal carcinoma cell lines.

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