Identification of the Sequence and the Length of Telomere DNA

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Authors

LYČKA Martin FAJKUS Petr JENNER Leon P. SÝKOROVÁ Eva FOJTOVÁ Miloslava PESKA Vratislav

Year of publication 2023
Type Chapter of a book
MU Faculty or unit

Central European Institute of Technology

Citation
Description Telomeres are essential nucleoprotein structures at the very ends of linear eukaryote chromosomes. They shelter the terminal genome territories against degradation and prevent the natural chromosome ends from being recognized by repair mechanisms as double-strand DNA breaks. There are two basic characteristics of telomeric DNA, its sequence and its length. The telomere sequence is important as a “landing area” for specific telomere-binding proteins, which function as signals and moderate the interactions required for correct telomere function. While the sequence forms the proper “landing surface” of telomeric DNA, its length is similarly important. Too short or exceptionally long telomere DNA cannot perform its function properly. In this chapter, methods for the investigation of these two basic telomere DNA characteristics are described, namely, telomere motif identification and telomere length measurement.
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