Vliv chemoterapie a následného intervenčního pohybového programu na aktivitu a balanci autonomního nervového systému – průběžné výsledky

Title in English The effect of chemotherapy and subsequent interventional exercise program on the activity and balance of the autonomic nervous system - interim results


Year of publication 2023
Type Article in Proceedings
Conference XLVII. Brněnské onkologické dny XXXVII., Konference pro nelékařské zdravotnické pracovníky, Laboratorní diagnostika v onkologii 2023. Sborník abstrakt.
MU Faculty or unit

Faculty of Sports Studies

Keywords oncology; autonomic nervous system; chemotherapy; physical activity
Description The autonomic nervous system (ANS) is considered the main regulatory homeostatic system of the body. One way to monitor and evaluate ANS activity is to measure heart rate variability (VSF). Higher VSF and especially higher parasympathetic activity is associated with longer survival and better prognosis of oncology patients. On the contrary, a low VSF is considered a factor of worse prognosis and increased cardiovascular risk. Chemotherapy with significant neurotoxicity is expected to have a negative effect on the ANS, thus the VSF. On the contrary, adequate regular physical activity has a positive effect on the activity and balance of the ANS. Patient recruitment started in September 2021, 26 patients aged 52.6 ± 12.2 years with a BMI of 25.7 ± 4.4 who were indicated for adjuvant chemotherapy based on platinum compounds, taxanes or vinca alkaloids were included in the analysis . During chemotherapy and subsequent intervention, patients were instructed to measure VSF 3 times a week using a chest belt and the MySASY application, the measurement took place in the form of a positional test. Patients were randomized into experimental (SAPA) and control (CO) groups. After completing chemotherapy, SAPA joined an online exercise intervention 3 times a week for 12 weeks. Each lesson lasted 60 minutes, the intensity of the main part was set to 60-80% VO2max. The parameters of total spectral power (TP), power in the low-frequency band (PLO) and high-frequency band (PHI) were compared before and after chemotherapy using the Wilcoxon test, before and after exercise intervention using the Wilcoxon test and the Mann-Whitney U test, and regression analysis of these data. During chemotherapy, all three parameters of TP (1201.0 ± 1051.2, 1050.9 ± 864.7, p = 0.328), PLO (412.8 ± 367.8, 336.7 ± 286.8, p = 0.209), PHI (493.2 ± 589.1, 423.2 ± 535.7, p = 0.381), no reduction was statistically significant. In the period after the end of chemotherapy, the TP and PHI parameters increased in both groups, the greater increase occurred in SAPA, the difference between the groups was not statistically significant TP (0.540) PHI (0.305). For the PLO parameter, there was an increase in SAPA values (742.7 ± 880.8, 845.8 ± 844.0), on the contrary, a decrease in CO values (379.1 ± 258.3, 345.7 ± 279.2) . Chemotherapy has a negative effect on the overall activity of the ANS and the performance of both its branches is reduced. After the end of chemotherapy, there is an increase in VSF parameters, in patients in the SAPA group there is a more significant increase, incl. the PLO parameter. Supported by the program project of the Ministry of Health of the Czech Republic with reg. no. NU21-09-00558. All rights under intellectual property laws are reserved.
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